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Symbol Name ID |
Lat
linker for activation of T cells MGI:1342293 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Defective T cell proliferation |
Decreased circulating IgA level |
Decreased circulating antibody level |
Abnormal B cell count |
Decreased proportion of CD4-positive T cells |
Increased proportion of gamma-delta T cells |
T lymphocytopenia |
Lymphopenia |
Abnormal natural killer cell count |
Autoimmune thrombocytopenia |
Persistent CMV viremia |
Persistent EBV viremia |
Lymphadenopathy |
Splenomegaly |
Recurrent pneumonia |
Immune dysregulation |
Immunodeficiency |
Recurrent infections |
| Disease(s) Associated with LAT | ||||||||||||||||||
| immunodeficiency 52 |
| Mouse Phenotypes | immune system phenotype |
phlebitis |
abnormal T cell proliferation |
increased T cell proliferation |
salivary gland inflammation |
abnormal thymus cell ratio |
small thymus |
thymus hypoplasia |
decreased thymocyte number |
abnormal thymocyte activation |
pancreas inflammation |
enlarged spleen |
increased spleen weight |
spleen hyperplasia |
abnormal lymphopoiesis |
abnormal B cell differentiation |
abnormal T cell differentiation |
abnormal T cell selection |
decreased double-negative T cell number |
decreased double-positive T cell number |
increased double-positive T cell number |
abnormal gamma-delta T cell differentiation |
arrested T cell differentiation |
increased susceptibility to autoimmune hemolytic anemia |
increased eosinophil cell number |
abnormal B cell number |
increased plasma cell number |
increased B cell number |
abnormal T cell subpopulation ratio |
increased T-helper 2 cell number |
decreased CD4-positive, alpha-beta T cell number |
absent CD4-positive, alpha-beta T cells |
increased CD4-positive, alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
absent CD8-positive, alpha-beta T cells |
absent mature gamma-delta T cells |
increased gamma-delta T cell number |
increased mature gamma-delta T cell number |
increased memory T cell number |
decreased regulatory T cell number |
decreased T cell number |
absent T cells |
increased T cell number |
abnormal lymphocyte morphology |
abnormal plasma cell morphology |
abnormal T cell morphology |
abnormal T-helper 2 cell morphology |
abnormal effector T cell morphology |
abnormal mature gamma-delta T cell morphology |
abnormal spleen morphology |
abnormal spleen white pulp morphology |
increased spleen germinal center number |
abnormal spleen periarteriolar lymphoid sheath morphology |
abnormal splenic cell ratio |
abnormal B cell activation |
increased IgE level |
increased IgG1 level |
increased IgM level |
increased immunoglobulin level |
abnormal T cell physiology |
abnormal T-helper 2 physiology |
abnormal T cell activation |
abnormal immune system morphology |
abnormal immune system organ morphology |
abnormal lymph node cell ratio |
abnormal lymph node secondary follicle morphology |
abnormal lymph node germinal center morphology |
enlarged lymph nodes |
abnormal immune system physiology |
abnormal immune serum protein physiology |
increased interferon-gamma secretion |
increased interleukin-4 secretion |
increased anti-erythrocyte antigen antibody level |
increased anti-nuclear antigen antibody level |
increased anti-chromatin antibody level |
chronic inflammation |
increased inflammatory response |
liver inflammation |
kidney inflammation |
glomerulonephritis |
lung inflammation |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lattm1.1Mal/Lattm1.1Mal | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lattm1Bpay/Lattm1Bpay | * | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lattm1Les/Lattm1Les | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lattm2.1Lov/Lattm2.1Lov | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lattm2.1Mal/Lattm2.1Mal | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lattm3.1Mal/Lattm3.1Mal | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lattm4.1Mal/Lattm4.1Mal | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lattm5.1Mal/Lattm5.1Mal | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lattm9Mal/Lattm9Mal | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lattm1Les/Lattm1.1Wz | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lattm1Les/Lattm1.2Wz | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lattm1Les/Lattm1.1Wz Tg(Cd4-cre)1Cwi/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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